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Cancer Development and Progression

Our Cancer Development & Progression program is focused on understanding the mechanisms of cancer growth and progression. This program integrates basic and applied research in areas such as genomic integrity, tumor microenvironment, inflammation, and hormone action. Our members provide important mechanistic insight into the process of tumorigenesis leading to new cancer prevention and treatment strategies, diagnostics, and biomarkers of cancer. Interdisciplinary collaborations with members of the Experimental & Developmental Therapeutics program and the Population Science & Prevention program further develop discoveries from bench to bedside and back.

The primary focus of the Cancer Development & Progression Program (CDP) is laboratory-based studies of fundamental problems in cancer etiology, but always with an eye toward translating the findings into clinical solutions for cancer patients. Research in the CDP program is focused in two major thematic areas: Genome Repair and Epigenetics and Tumor Microenvironment.


Integrate basic and translational research in genomic integrity, age-related cancer susceptibility, hormone actions and chronic inflammation to obtain a deeper and broader picture of cancer development and progression.

Foster transdisciplinary, synergistic and high complementary collaboration between basic and translational research within the CDP program and in the Experimental & Developmental Therapeutics and Population Science & Prevention programs and translate laboratory findings into novel approaches in cancer prevention and treatment.