Saba Shaikh, MD Breast Oncology , Hematology Oncology
Jessica Treviño Jones, MD Breast Oncology , Cancer Genetics and High-Risk Screening
Roberto Martinez, MD Breast Reconstructive Surgery, Plastic Surgery
Marcela Mazo Canola, MD Breast Oncology, Medical Oncology
Andrew Brenner, MD Neuro-Oncology, Breast Oncology
Rayaad Hosein, MD Breast Reconstruction, Plastic Surgery
David Gius, MD, PhD Breast Oncology , Radiation Oncology
A Randomized Phase II Study of Partial Breast Irradiation and Sequential vs. Concurrent Chemotherapy in Women with Early Stage Breast Cancer (PBI 3.0). CTMS#: 17-0048
In a small study at Johns Hopkins, women were treated with partial breast irradiation and chemotherapy given at the same time. We are now testing in a bigger study whether giving partial breast irradiation and chemotherapy at the same time (our new method) has the same side effects and outcomes as giving partial breast irradiation and chemotherapy at different times(older method). In this study women who had their breast cancer removed but need radiation to the breast will be randomized to partial breast irradiation at the same time as chemotherapy or partial breast radiation at a different time than chemotherapy. Randomization is like flipping a coin but in this study about 2 of every 3 women will get the new method.
Shortening Adjuvant PHoton IRradiation (SAPHIRe): A Randomized Trial of Hypofractionated Versus Conventionally Fractionated Regional Nodal Irradiation for Invasive Breast Cancer (CTMS# 23-0020)
To compare how often cancer recurs (comes back) after 3 weeks of radiation compared to 5 weeks of radiation in patients who receive radiation therapy delivered to the lymph nodes near the breast. The side effects that can develop during or after radiation treatment, including how often arm swelling (edema) happens, will also be studied