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Reducing Sleep disTurbance in Cancer (REST-C): A study to compare the effectiveness of two different wellness-based mobile apps on blood cancer patient outcomes

Principal Investigators

dr mesa


Ruben Mesa MD, FACP, is the vice dean for cancer programs at Wake Forest University School of Medicine and executive director of the Atrium Health Wake Forest Baptist Comprehensive Cancer Center. He is an internationally known expert who has dedicated his career to research and drug development for blood cancers and disorders.


dr huberty


Jen Huberty, PhD is an accomplished behavior research scientist with over 20 years of experience leading academic and industry-based science using digital approaches to change behavior and improve well-being.



Supreet Kaur, MD


Supreet Kaur, MD is a hematologist oncologist at the Mays Cancer Center, home to UT Health San Antonio MD Anderson Cancer Center. Her current research interests include clinical biomarkers in cancer and therapeutics. She serves as principal investigator and co-investigator in a number of clinical trials, including SWOG cooperative group studies.


About this study

This trial aims to study the effectiveness of two different wellness-based mobile apps on blood cancer patient outcomes, including sleep, fatigue, anxiety, depression, and blood biomarkers of inflammation (TNF-a, IL-6, IL-8, CRP). The findings of this study may help physicians and researchers better understand how mobile wellness mobile apps can help in managing symptom burden and inflammation in blood cancer patients.

Participation eligibility

Participant eligibility includes factors such as age, cancer diagnosis, treatment status, and more. See below for a complete list of all eligibility criteria that is required for participation in this trial.

Inclusion Criteria:

  • Currently diagnosed with a blood cancer and currently undergoing treatment
  • Not currently participating in a therapeutic pharmacologic clinical trial
  • Has not received/planning to receive an allogenic stem cell transplantation
  • Moderate sleep disturbances or problems with sleep
  • Own a mobile smartphone (iPhone with iOS 14 or later or an Android 6 or later)
  • Willing to download a mobile app
  • Able to read/understand English
  • 18 years of age or older
  • Willing to be randomized
  • Willing to drive to a nearby lab for blood draws 3x during the study over the course of 20 weeks (8-week intervention period followed by 12-week follow-up period)
  • No change in prescribed or over-the-counter sleep medication use (if any) over the past six weeks (including drugs like NyQuil, Benadryl, and other anti-histamine-based drugs)

Exclusion Criteria

  • Current meditation practice or meditative movement practice (i.e., yoga, tai chi, qi gong) of ≥60 min/week in past 2 months
  • Reside outside of the United States of America
  • Any planned change in pharmacologic therapy (i.e., new drug) or allogenic stem cell transplantation during study timeframe (i.e., 20 weeks)
  • Currently diagnosed with a sleep disorder, except insomnia
  • Currently taking prescribed sleep medications, over-the-counter drugs, and/or supplements >3 times per week (including drugs like NyQuil, Benadryl, and other anti-histamine-based drugs)
  • Any other diagnosed and uncontrolled medical or psychiatric condition
  • Younger than 18 years of age.