Clinical Trials

AREN0533. Treatment of Newly Diagnosed Higher Risk Favorable Histology Wilms Tumors. A Groupwide Phase III Study

ClinicalTrials.gov Identifier

NCT00379340

Principal Investigator

Anne–Marie Langevin MD

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About This Study

This phase III trial is studying how well combination chemotherapy with or without radiation therapy works in treating young patients with newly diagnosed stage III or stage IV Favorable Histology Wilms' tumor. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving more than one drug (combination chemotherapy) with or without radiation therapy may kill more tumor cells.