Clinical Trials

S2209, A Phase III Randomized Trial For Newly Diagnosed Multiple Myeloma (NDMM) Patients Considered Frail Or In A Subset of “Intermediate Fit” Comparing Upfront Three-Drug Induction Regimens Followed by Double- or Single-Agent Maintenance

Cancer Type

Myeloma

ClinicalTrials.gov Identifier

ClinicalTrials.gov registration not required

Principal Investigator

Matthew Butler, MD

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About This Study

To compare progression-free survival (PFS) in frail or selected intermediate fit Newly Diagnosed Multiple Myeloma (NDMM) participants treated with VRd-Lite induction followed by Lenalidomide maintenance (Arm 1) versus DRd induction followed by Lenalidomide maintenance (Arm 2).To compare overall survival (OS) in frail or selected intermediate fit NDMM participants treated with VRd-Lite induction followed by lenalidomide maintenance (Arm 1) versus DRd induction followed by lenalidomide and daratumumab and hyaluronidase-fihj maintenance (Arm 3).